Our overarching goal is to understand DNA replication at the molecular level. We are utilizing innovative biophysical tools and approaches to assess the structural nature and the biomolecular interactions in protein-protein and protein-nucleic acid complexes, and, in turn, we learn how these interactions determine and impact biological catalysis of DNA replication. Our interdisciplinary approach, spanning and integrating chemistry and biology, employs a wide range of techniques.
In our lab we study the interplay between proteins and nucleic acids of the DNA replication machinery in bacteria and related systems. The imminent need for the development of new antibacterial drugs will lead us to develop inhibitors targeted against components in the bacterial replisome.